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Four adult outpatients suffering from severe, chronic sleep onset insomnia participated in a five-session paradoxical instruction treatment program. A multiple baseline design across subjects was utilized with major dependent measures consisting of eight behaviorally-specific daily sleep indices. Counterdemand manipulations were applied so as to evaluate and control for change attributable to.

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Christina Kiel 1, 2, 4; 1 Systems Biology Ireland, University College Dublin, Belfield, Dublin 4,

RAF inhibitors cause a paradoxical activation of ERK because they promote the dimerization of BRAF with CRAF, subverting a normally transient element of physiological RAF activation into a long-lasting change of ERK activation dynamics,